Abstract Search

ea0063gp154 | Cushing's | ECE2019

Pathway enrichment analysis in functioning and silent corticotroph pituitary adenomas reveals mechanisms to explain their distinct clinical behaviour

Olarescu Nicoleta Cristina , Normann Kjersti Ringvoll , Sundaram Arvind YM , Oystese Kristin Astrid Berland , Eieland Alexander , Lekva Tove , Bollerslev Jens

Background: Functioning (FCA) and silent corticotroph (SCA) pituitary adenomas act differently from a clinical perspective, despite both subtypes showing positive ACTH staining by immunohistochemistry. They are challenging to treat, the former due to functional ACTH production and consequently hypercortisolemia leading to Cushing disease, whereas the latter due to invasive and recurrent behaviour. Moreover, the molecular mechanisms behind their distinct behaviour are not clear...

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ea0049oc8.3 | Neuroendocrinology | ECE2017

RNA sequencing and RT-qPCR identify different gene expression profiles in fast- vs. slow-growing non-functioning pituitary adenomas

Falch Camilla Maria , Sundaram Arvind Y.M. , Oystese Kristin Astrid Berland , Normann Kjersti Ringvoll , Silamikelis Ivars , Andersen Marianne , Bollerslev Jens , Olarescu Nicoleta Cristina

Background: Non-functioning pituitary adenomas (NFPAs) necessitate prolonged clinical, biochemical and radiological observation, constituting a significant burden in terms of medical resources and societal costs. Reliable biomarkers associated with aggressiveness and recurrence of NFPAs are lacking. As the growth of tumor remnants is highly variable, molecular markers that can predict growth potential and tumor behavior are necessary.Aim: To identify tar...

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Endocrine Abstracts

Pathway enrichment analysis in functioning and silent corticotroph pituitary adenomas reveals mechanisms to explain their distinct clinical behaviour

RNA sequencing and RT-qPCR identify different gene expression profiles in fast- vs. slow-growing non-functioning pituitary adenomas

BiosciAbstracts